Zebrafish Reel in Phenotypic Suppressors of Autism
نویسندگان
چکیده
Chemical genetics can help decipher novel pathways underlying neurodevelopmental psychiatric impairments. Hoffman et al. (2016) utilized behavioral profiling of psychoactive compounds in zebrafish and identified estrogens as suppressors of a phenotype resulting from loss of an autism risk gene.
منابع مشابه
Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2
Autism spectrum disorders (ASDs) are a group of devastating neurodevelopmental syndromes that affect up to 1 in 68 children. Despite advances in the identification of ASD risk genes, the mechanisms underlying ASDs remain unknown. Homozygous loss-of-function mutations in Contactin Associated Protein-like 2 (CNTNAP2) are strongly linked to ASDs. Here we investigate the function of Cntnap2 and und...
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Wheat as a main food source is partly lost in different ways such as planting, harvesting, storage and even in consumption processes. This calls for attention to reducing these losses through application of the results from agricultural research, use of new farming practices, improvements in management system and repair and renewal of farm machinery. The present study considers the design, deve...
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عنوان ژورنال:
- Neuron
دوره 89 شماره
صفحات -
تاریخ انتشار 2016